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Groeger M, Matsuo K, Heidary Arash E, Pereira A, Le Guillou D, Pino C, Telles-Silva KA, Maher JJ, Hsiao EC, Willenbring H
Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages.
Nature communications, 2023-07-03.
Qi L, Matsuo K, Pereira A, Lee YT, Zhong F, He Y, Zushin PH, Gr?ger M, Sharma A, Willenbring H, Hsiao EC, Stahl A
Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System.
Small (Weinheim an der Bergstrasse, Germany), 2023-04-27.
Laemmle A, Häberle J, Willenbring H
Reply to "The Role of Aquaporin 9 in Modeling of Ornithine Transcarbamylase Deficiency".
Hepatology (Baltimore, Md.), 2021-12-21.
Laemmle A, Poms M, Hsu B, Borsuk M, Rüfenacht V, Robinson J, Sadowski MC, Nuoffer JM, Häberle J, Willenbring H
Aquaporin 9 Induction in Human iPSC-derived Hepatocytes Facilitates Modeling of Ornithine Transcarbamylase Deficiency.
Hepatology (Baltimore, Md.), 2021-11-16.
Lee-Montiel FT, Laemmle A, Charwat V, Dumont L, Lee CS, Huebsch N, Okochi H, Hancock MJ, Siemons B, Boggess SC, Goswami I, Miller EW, Willenbring H, Healy KE
Integrated Isogenic Human Induced Pluripotent Stem Cell-Based Liver and Heart Microphysiological Systems Predict Unsafe Drug-Drug Interaction.
Frontiers in pharmacology, 2021-05-07.
Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ
iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile.
Gastroenterology, 2021-02-25.
Emerging cell therapy for biliary diseases.
Science (New York, N.Y.), 2021-02-19.
Kurial SNT, Willenbring H
Transcriptomic traces of adult human liver progenitor cells.
Hepatology (Baltimore, Md.), 2020-01-28.
Chen F, Jimenez RJ, Sharma K, Luu HY, Hsu BY, Ravindranathan A, Stohr BA, Willenbring H
Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration.
Cell stem cell, 2019-12-19.
Huck I, Gunewardena S, Espanol-Suner R, Willenbring H, Apte U
Hepatocyte Nuclear Factor 4 alpha (HNF4a) Activation is Essential for Termination of Liver Regeneration.
Hepatology (Baltimore, Md.), 2018-12-05.
Schaub JR, Huppert KA, Kurial SNT, Hsu BY, Cast AE, Donnelly B, Karns RA, Chen F, Rezvani M, Luu HY, Mattis AN, Rougemont AL, Rosenthal P, Huppert SS, Willenbring H
De novo formation of the biliary system by TGFß-mediated hepatocyte transdifferentiation.
Nature, 2018-05-02.
Ian Huck,Sumedha Gunewardena,Regina Espanol-Suner,Holger Willenbring,Udayan Apte
Hepatocyte Nuclear Factor 4 alpha (HNF4a) Activation is Essential for Termination of Liver Regeneration.
bioRxiv, 2018-04-20.
Abou-Alfa GK, Andersen JB, Chapman W, Choti M, Forbes SJ, Gores GJ, Hong TS, Harding JJ, Vander Heiden MG, Javle M, Kelley RK, Kwong LN, Lowery M, Merrell A, Miyabe K, Rhim A, Saha S, Sia D, Tanasanvimon S, Venook A, Valle JW, Walesky C, Whetstine J, Willenbring H, Zhu AX, Mayer D, Stanger BZ
Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference.
Journal of gastrointestinal oncology, 2016-12-01.
Rezvani M, Español-Suñer R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman JG, Wiedtke E, Hsu BY, Naqvi SJ, Schwabe RF, Corvera CU, Grimm D, Willenbring H
In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis.
Cell stem cell, 2016-06-02.
Rezvani M, Grimm AA, Willenbring H
Assessing the therapeutic potential of lab-made hepatocytes.
Hepatology (Baltimore, Md.), 2016-05-26.
Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT
Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.
Hepatology (Baltimore, Md.), 2016-03-09.
Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H
A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
Hepatology (Baltimore, Md.), 2014-11-24.
Hentzschel F, Hammerschmidt-Kamper C, Börner K, Heiss K, Knapp B, Sattler JM, Kaderali L, Castoldi M, Bindman JG, Malato Y, Willenbring H, Mueller AK, Grimm D
AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites.
Molecular therapy : the journal of the American Society of Gene Therapy, 2014-09-05.
Johanna R. Schaub,Yann Malato,Coralie Gormond,Holger Willenbring
Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury.
Cell Reports, 2014-09-01.
Schaub JR, Malato Y, Gormond C, Willenbring H
Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury.
Cell reports, 2014-08-14.
Espejel S, Eckardt S, Harbell J, Roll GR, McLaughlin KJ, Willenbring H
Brief report: Parthenogenetic embryonic stem cells are an effective cell source for therapeutic liver repopulation.
Stem cells (Dayton, Ohio), 2014-07-01.
Lee RH, Roll G, Nguyen V, Willenbring H, Tang Q, Kang SM, Stock PG
Failure to achieve normal metabolic response in non-obese diabetic mice and streptozotocin-induced diabetic mice after transplantation of primary murine hepatocytes electroporated with the human proinsulin gene (p3MTChins).
Transplantation proceedings, 2014-07-01.
Ng R, Wu H, Xiao H, Chen X, Willenbring H, Steer CJ, Song G
Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia.
Hepatology (Baltimore, Md.), 2014-05-19.
Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S
Mouse liver repopulation with hepatocytes generated from human fibroblasts.
Nature, 2014-02-23.
Mitchell C, Willenbring H
Addendum: A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice.
Nature protocols, 2014-01-01.
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