Yann Malato, Ph.D.
- Senior Research Associate, Genentech
Education
2009, Ph.D. Role of the IKK complex during liver regeneration, University Hospital Aachen, Aachen, Germany.
2005, MASTER 2 Cell Biology and Physiopathology, GREF, INSERM E0362, Universite Victor Segalen Bordeaux 2, Bordeaux (France).
2004, MASTER 1 Cell Biology and Physiopathology, Universite Bordeaux 1 - Bordeaux 2, Bordeaux (France).
2003, LICENCE Cell Biology and Physiology, (Neuroscience), Universite Bordeaux 1, Bordeaux (France).
2002, DEUG Life Sciences, Universite Bordeaux 1, Bordeaux (France).
2000, Classe preparatoire aux grandes Ecoles » BCPST, Lycee Michel Montaigne Bordeaux (France)
1999, "Baccalaureat serie Scientifique" (required for university entrance)
Biography
Yann Malato, Ph.D. is a post-doctoral fellow in the Willenbring Lab. Born and raised in France, Dr. Malto trained in Bordeaux, France at the University Bordeaux 1 and Bordeaux 2. In 2005, he joined the laboratory of Dr. Christian Trautwein in Aachen, Germany, attended gradudate school there and earned his Ph.D. in November 2009. He then joined the lab of Dr. Willenbring where as the senior post-doc, he manages the training all new members of the lab.
Research Overview
Dr. Malato is now working on liver fibrosis, the project's purpose is to reduce fibrosis by turning fibrotic cells (myofibroblasts) into healthy hepatocytes. He is also studying the effects of a lack of mature microRNAs in the mouse liver and its impact on hepatocarcinogenesis. Dr. Malato previous work established a new model of lineage tracing in the liver, genetically marking hepatocytes and following their outcomes after several models of liver injuries. This is called "fate tracing of mature hepatocytes". The cell of origin of liver cancers is another research interest.
In the News
- Willenbring Lab - - June 03, 2016UCSF News reports on the research of the Willenbring Lab and others demonstrating in mice that healthy new liver cells could be generated within the organ itself, thus making engraftment unnecessary. The article noted that the very cells that drive liver disease were converted, thereby reducing liver damage and improving liver function simultaneously. The study was recently reported on in a paper published by the journal Cell Stem Cell. Advances in stem cell research have made it possible [...]
