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Willenbring Lab »  Alumni »  Postdoctoral Fellows »  Aras N. Mattis, M.D., Ph.D.
Aras N. Mattis, M.D., Ph.D.

Aras N. Mattis, M.D., Ph.D.

  • Assistant Professor, UCSF Department of Pathology
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University of California, Berkeley, B.A., Molecular and Cell Biology, 1998

University of Illinois, Chicago, M.D., Medicine, 2007

University of Illinois, Urbana-Champaign, Ph.D., Biochemistry, 2007

University of California, San Francisco, Anatomic Pathology Resident 2007-2009

University of California, San Francisco, Fellow, Surgical Pathology, 2009-2010

University of California, San Francisco, Fellow, Liver/GI Pathology, 2010-Present

  • American Board of Pathology, Anatomic Pathology
  • UCSF Department of Pathology
  • California Institute for Regenerative Medicine
  • Liver and Gastrointestinal Pathology
  • Development and metabolism, liver and gastrointestinal tumors, site-specific recombination.
  • Hepatocytes for transplant and disease modeling, micro-RNA regulation of hepatocyte
  • Liver diseases including metabolic, pediatric, fibrotic, idiopathic, stem cell derived

Aras N. Mattis, M.D., Ph.D., is a board-certified anatomic pathologist and clinical fellow in the Willenbring Lab. Dr. Mattis trained at the University of Illinois at Urbana-Champaign, earning both his doctorates, Biochemistry and Medicine, there in 2007. He continued his clinical training in Pathology at the University of California San Francisco completing residency in Anatomic Pathology with subsequent fellowship training in Surgical Pathology and Liver and gastrointestinal pathology under his clinical mentor, Dr. Linda Ferrell. Since 2010, he has worked in the Willenbring Lab, investigating the basic mechanisms of liver development and disease in the with a specific focus on liver metabolism and fatty liver disease as well as micro-RNA regulation of liver metabolism.

Dr. Mattis' postdoctoral work includes the use of translational human biopsy material as well as patient-derived induced pluripotent stem cell reprogramming to hepatocytes. As a long-term goal, this work aims to develop a humanized liver mouse model of fatty liver disease. Aras is supported by the UCSF CIRM clinical fellow training grant and continues to work closely with the UCSF Department of Pathology as a clinical researcher.

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  • Genetic Regulation of Nonalcoholic Fatty Liver Disease
    Sponsor:
    Sponsor ID:
    Funding Period:
    Jun 2021
    -
    Mar 2025
    Co-Principal Investigator
  • Regulation of Lipid Metabolism by miR-29a within Hepatocytes
    Sponsor:
    Sponsor ID:
    Funding Period:
    Sep 2013
    -
    Jul 2018
    Principal Investigator
MOST RECENT PUBLICATIONS FROM A TOTAL OF 44
Data provided by UCSF Profiles, powered by CTSI
  1. Akanuma N, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT. Fundic Gland Polyps Lack DNA Content Abnormality Characteristic of Other Adenomatous Precursor Lesions in the Gastrointestinal Tract. Mod Pathol. 2023 Feb 01; 36(5):100117. View in PubMed
  2. Weng Y, Han S, Sekyi MT, Su T, Mattis AN, Chang TT. Self-Assembled Matrigel-Free iPSC-Derived Liver Organoids Demonstrate Wide-Ranging Highly Differentiated Liver Functions. Stem Cells. 2023 Mar 02; 41(2):126-139. View in PubMed
  3. Pierce GF, Mattis AN. Transient expression of factor VIII and a chronic high-fat diet induces ER stress and late hepatocyte oncogenesis. Mol Ther. 2022 12 07; 30(12):3510-3512. View in PubMed
  4. Yu A, Cable C, Sharma S, Shihan MH, Mattis AN, Mileva I, Hannun YA, Duwaerts CC, Chen JY. Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis. Front Med (Lausanne). 2022; 9:881848. View in PubMed
  5. Muñoz A, Theusch E, Kuang YL, Nalula G, Peaslee C, Dorlhiac G, Landry MP, Streets A, Krauss RM, Iribarren C, Mattis AN, Medina MW. Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease. Cell Mol Gastroenterol Hepatol. 2022; 14(5):1174-1176.e6. View in PubMed
  6. View All Publications

 

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